:root{--bg-primary: #ffffff;--bg-secondary: #f5f5f5;--surface-card: #ffffff;--text-primary: #171717;--text-muted: #a3a3a3;--border-primary: #e5e5e5;--error: #f85149;--accent: #ff9900;--font-sans: "Inter", -apple-system, system-ui, sans-serif}[data-theme=dark]{--bg-primary: #0a0a0a;--bg-secondary: #171717;--surface-card: #1a1a1a;--text-primary: #fafafa;--text-muted: #737373;--border-primary: #262626}*{margin:0;padding:0;box-sizing:border-box}body{font-family:var(--font-sans);background:var(--bg-primary);color:var(--text-primary)}a{color:var(--accent);text-decoration:none}a:hover{text-decoration:underline}.app-shell{display:flex;min-height:100vh}.app-sidebar{width:240px;background:#1a1a2e;color:#e0e0e0;display:flex;flex-direction:column;padding:16px;flex-shrink:0}.sidebar-brand{margin-bottom:24px}.sidebar-brand-name{font-size:16px;font-weight:700;color:#fff}.sidebar-nav{display:flex;flex-direction:column;gap:2px;flex:1}.nav-item{background:none;border:none;color:#a0a0b0;padding:8px 12px;border-radius:6px;cursor:pointer;text-align:left;font-size:13px;text-decoration:none;display:block}.nav-item:hover,.nav-item.active{background:#ffffff14;color:#fff;text-decoration:none}.nav-item--sub{padding-left:20px;font-size:12px}.sidebar-context{margin-top:12px;padding-top:12px;border-top:1px solid rgba(255,255,255,.08)}.sidebar-context__title{font-size:11px;color:#6b7280;text-transform:uppercase;letter-spacing:.04em;margin-bottom:4px;padding:0 12px}.sidebar-footer{border-top:1px solid rgba(255,255,255,.1);padding-top:12px;display:flex;justify-content:space-between;align-items:center}.sidebar-user{display:flex;align-items:center;gap:8px}.sidebar-user-avatar{width:28px;height:28px;border-radius:50%;background:var(--accent);color:#fff;display:flex;align-items:center;justify-content:center;font-size:11px;font-weight:700}.sidebar-user-name{font-size:12px;color:#c0c0d0}.theme-toggle{background:none;border:none;color:#a0a0b0;cursor:pointer;font-size:16px;padding:4px}.app-main{flex:1;overflow-y:auto}.app-content{padding:24px;max-width:1200px}.view-header{display:flex;justify-content:space-between;align-items:center;margin-bottom:20px;gap:16px}.view-title{font-size:22px;font-weight:700}.view-subtitle{font-size:13px;color:var(--text-muted);margin-top:4px}.section-title{font-size:14px;font-weight:600;margin-bottom:12px}.card{background:var(--surface-card);border:1px solid var(--border-primary);border-radius:10px}.muted{color:var(--text-muted)}.splash{display:flex;flex-direction:column;justify-content:center;align-items:center;height:100vh}.splash__title{font-size:24px;font-weight:700}.splash__sub{color:var(--text-muted);font-size:13px;margin-top:8px}.btn{border:1px solid var(--border-primary);background:var(--surface-card);color:var(--text-primary);padding:8px 14px;border-radius:6px;cursor:pointer;font-size:13px;font-weight:500}.btn:hover:not(:disabled){border-color:var(--accent)}.btn:disabled{opacity:.5;cursor:not-allowed}.btn-primary{background:var(--accent);color:#fff;border-color:var(--accent)}.btn-secondary{background:transparent}.btn-sm{padding:4px 8px;font-size:11px}.breadcrumb{font-size:12px;color:var(--text-muted);margin-bottom:12px}.tabs{display:flex;gap:4px;border-bottom:1px solid var(--border-primary)}.tab{padding:8px 12px;font-size:13px;color:var(--text-muted);text-decoration:none;border-bottom:2px solid transparent}.tab:hover{text-decoration:none;color:var(--text-primary)}.tab--active{color:var(--text-primary);border-bottom-color:var(--accent)}.upload-zone{border:2px dashed var(--border-primary);border-radius:12px;padding:48px 16px;text-align:center;cursor:pointer;transition:border-color .2s}.upload-zone--over{border-color:var(--accent);background:#ff99000d}.upload-zone__icon{display:inline-block;padding:6px 12px;border:1px solid var(--border-primary);border-radius:6px;font-weight:700;margin-bottom:12px}.upload-zone__title{font-size:16px;font-weight:600}.upload-zone__subtitle{font-size:12px;color:var(--text-muted);margin-top:4px}.upload-progress{margin-top:16px;display:flex;align-items:center;gap:8px;font-size:13px}.protocol-summary-card{padding:16px;margin-top:16px}.protocol-summary-card__header{display:flex;align-items:flex-start;justify-content:space-between;gap:12px;margin-bottom:14px}.protocol-summary-grid{display:grid;grid-template-columns:repeat(3,minmax(0,1fr));gap:12px;margin-bottom:12px}.protocol-summary-label{font-size:10px;color:var(--text-muted);text-transform:uppercase;letter-spacing:.04em;margin-bottom:4px}.protocol-summary-value{font-size:13px;font-weight:600}.protocol-summary-card__footer{display:flex;justify-content:space-between;align-items:center;gap:12px;margin-top:12px;padding-top:12px;border-top:1px solid var(--border-primary)}.ai-source{display:inline-flex;align-items:center;border-radius:999px;padding:4px 10px;font-size:11px;font-weight:700;border:1px solid var(--border-primary);white-space:nowrap}.ai-source--bedrock{color:#3fb950;border-color:#3fb950;background:#3fb9501a}.ai-source--fixture_fallback,.ai-source--demo_fixture{color:var(--accent);border-color:var(--accent);background:#ff99001a}.spinner{width:14px;height:14px;border:2px solid var(--border-primary);border-top-color:var(--accent);border-radius:50%;animation:spin .8s linear infinite}@keyframes spin{to{transform:rotate(360deg)}}.skeleton{display:flex;flex-direction:column;gap:8px}.skeleton-row{background:linear-gradient(90deg,var(--bg-secondary),var(--border-primary),var(--bg-secondary));background-size:200% 100%;border-radius:4px;animation:shimmer 1.4s infinite}@keyframes shimmer{0%{background-position:200% 0}to{background-position:-200% 0}}.error-state{background:var(--surface-card);border:1px solid var(--error);border-radius:10px;padding:16px}.error-state__title{font-weight:600;color:var(--error)}.error-state__msg{color:var(--text-muted);font-size:13px;margin-top:4px;margin-bottom:8px}.status-badge{display:inline-block;padding:4px 10px;border-radius:999px;font-size:11px;font-weight:600;color:#fff;text-transform:uppercase;letter-spacing:.04em}.progress-track{height:6px;background:var(--bg-secondary);border-radius:3px;overflow:hidden}.progress-fill{height:100%;background:var(--accent);transition:width .3s ease}.site-list{display:flex;flex-direction:column;gap:12px}.site-card{padding:16px}.site-card__header{display:flex;align-items:flex-start;gap:12px}.site-card__rank{font-size:18px;font-weight:700;color:var(--text-muted);min-width:32px}.site-card__title-wrap{flex:1}.site-card__title{font-size:15px;font-weight:600}.site-card__narrative{font-size:12px;color:var(--text-muted);margin-top:4px}.site-card__score{font-size:28px;font-weight:700;min-width:60px;text-align:right}.site-card__bars{display:grid;grid-template-columns:repeat(5,1fr);gap:8px;margin-top:12px}.site-card__bar{display:flex;flex-direction:column;gap:4px}.site-card__bar-label{font-size:10px;color:var(--text-muted);text-transform:uppercase;letter-spacing:.03em}.site-card__bar-track{height:6px;background:var(--bg-secondary);border-radius:3px;overflow:hidden}.site-card__bar-fill{height:100%}.site-card__bar-value{font-size:11px;font-weight:600}.site-card__flags{display:flex;gap:6px;margin-top:12px;flex-wrap:wrap}.site-card__footer{display:flex;justify-content:space-between;align-items:center;margin-top:12px;padding-top:12px;border-top:1px solid var(--border-primary)}.site-card__meta{font-size:12px;color:var(--text-muted)}.flag-badge{display:inline-block;font-size:10px;padding:2px 8px;border:1px solid;border-radius:999px;font-weight:600}.sub-score-badge{border:1px solid;border-radius:8px;padding:12px;min-width:100px}.sub-score-badge__label{font-size:10px;color:var(--text-muted);text-transform:uppercase;letter-spacing:.04em}.sub-score-badge__value{font-size:24px;font-weight:700;margin-top:4px}.sub-score-grid{display:grid;grid-template-columns:repeat(auto-fit,minmax(120px,1fr));gap:12px}.composite-score{font-size:36px;font-weight:700}.evidence-list{list-style:none;display:flex;flex-direction:column;gap:8px}.evidence-item{padding:8px 0;border-bottom:1px solid var(--border-primary)}.evidence-item__claim{font-size:13px}.evidence-item__meta{display:flex;gap:8px;flex-wrap:wrap;align-items:center;margin-top:4px;font-size:11px}.evidence-item__link{color:var(--accent)}.evidence-item__date{color:var(--text-muted)}.source-chip{display:inline-block;font-size:10px;padding:2px 8px;background:var(--bg-secondary);border-radius:999px;border:1px solid var(--border-primary);cursor:pointer}.alert{padding:12px 16px;border-radius:8px;font-size:13px}.alert--critical{background:#f851491a;color:var(--error);border:1px solid var(--error)}.alert--ok{background:#3fb9501a;color:#3fb950;border:1px solid #3fb950}.data-table{width:100%;border-collapse:collapse;font-size:13px}.data-table th,.data-table td{padding:8px 12px;text-align:left;border-bottom:1px solid var(--border-primary)}.data-table th{font-weight:600;color:var(--text-muted);font-size:11px;text-transform:uppercase}.chat-layout{display:grid;grid-template-columns:2fr 1fr;gap:16px}.chat-thread{display:flex;flex-direction:column;gap:12px;min-height:320px;padding:12px 0}.chat-msg{padding:10px 12px;border-radius:8px;max-width:85%}.chat-msg--user{background:var(--bg-secondary);align-self:flex-end}.chat-msg--assistant{background:var(--surface-card);border:1px solid var(--border-primary)}.chat-msg__text{font-size:13px;white-space:pre-wrap}.chat-citations{display:flex;gap:6px;margin-top:8px;flex-wrap:wrap}.chat-input{display:flex;gap:8px;margin-top:12px}.chat-input input{flex:1;padding:10px 12px;border:1px solid var(--border-primary);border-radius:8px;background:var(--bg-primary);color:var(--text-primary);font-size:13px}.pinned-list{list-style:none;display:flex;flex-direction:column;gap:8px;font-size:12px}.popover{position:fixed;inset:0;background:#00000080;display:flex;align-items:center;justify-content:center;z-index:100}.popover__panel{background:var(--surface-card);border:1px solid var(--border-primary);border-radius:10px;padding:16px;max-width:720px;width:90%}.popover__header{display:flex;justify-content:space-between;align-items:center;margin-bottom:12px}.popover__code{background:var(--bg-secondary);padding:12px;border-radius:6px;font-size:12px;overflow-x:auto;white-space:pre-wrap}.weight-row{display:grid;grid-template-columns:200px 1fr 60px;align-items:center;gap:12px;padding:6px 0}.weight-row label{font-size:13px}.weight-value{font-size:13px;font-weight:600;text-align:right}.weight-sum{margin:8px 0;font-size:13px;font-weight:600}.weight-sum.ok{color:#3fb950}.weight-sum.err{color:var(--error)}@media(max-width:760px){.protocol-summary-card__header,.protocol-summary-card__footer{flex-direction:column;align-items:flex-start}.protocol-summary-grid{grid-template-columns:1fr}}.pi-profile__header{display:flex;justify-content:space-between;align-items:flex-start;gap:16px;flex-wrap:wrap}.pi-profile__name{font-size:1.1rem;font-weight:600;margin-bottom:2px}.pi-profile__institution{font-size:.9rem;opacity:.85}.pi-profile__specialty{font-size:.85rem;opacity:.7;margin-top:2px}.pi-profile__npi{font-size:.85rem;opacity:.8;white-space:nowrap}.pi-profile__stats{display:flex;gap:24px;flex-wrap:wrap;margin-top:16px;padding-top:16px;border-top:1px solid var(--border, #e0e0e0)}.pi-stat{text-align:center;min-width:72px}.pi-stat__value{font-size:1.4rem;font-weight:700;color:var(--accent, #0073bb)}.pi-stat__label{font-size:.75rem;opacity:.7;margin-top:2px}.pi-profile__flags{margin-top:12px;padding:8px 12px;background:var(--error-bg, #fef2f2);border-radius:6px;font-size:.85rem}.cost-summary__headline{display:flex;gap:32px;align-items:flex-start;flex-wrap:wrap}.cost-summary__per-patient,.cost-summary__total{text-align:center}.cost-summary__amount{font-size:1.3rem;font-weight:700}.cost-summary__label{font-size:.75rem;opacity:.7;margin-top:2px}.cost-summary__comparison{display:flex;flex-direction:column;align-items:center;gap:4px}.cost-summary__delta{font-size:.8rem;opacity:.75}.cost-breakdown{margin-top:20px;padding-top:16px;border-top:1px solid var(--border, #e0e0e0)}.cost-breakdown__title{font-size:.9rem;font-weight:600;margin-bottom:12px}.cost-breakdown__items{display:flex;flex-direction:column;gap:8px}.cost-breakdown__row{display:grid;grid-template-columns:1fr 120px auto auto;gap:12px;align-items:center;font-size:.85rem}.cost-breakdown__category{white-space:nowrap;overflow:hidden;text-overflow:ellipsis}.cost-breakdown__bar-container{height:8px;background:var(--border, #e0e0e0);border-radius:4px;overflow:hidden}.cost-breakdown__bar{height:100%;background:var(--accent, #0073bb);border-radius:4px;transition:width .3s ease}.cost-breakdown__amount{font-weight:500;text-align:right;white-space:nowrap}.cost-breakdown__pct{opacity:.6;min-width:32px;text-align:right}.cost-notes{margin-top:12px;font-size:.85rem;font-style:italic;opacity:.75}.badge{display:inline-block;padding:2px 8px;border-radius:12px;font-size:.75rem;font-weight:600}.badge--success{background:#dcfce7;color:#166534}.badge--info{background:#dbeafe;color:#1e40af}.badge--warning{background:#fef3c7;color:#92400e}.badge--error{background:#fef2f2;color:#991b1b}[data-theme=dark] .badge--success{background:#052e16;color:#86efac}[data-theme=dark] .badge--info{background:#172554;color:#93c5fd}[data-theme=dark] .badge--warning{background:#451a03;color:#fcd34d}[data-theme=dark] .badge--error{background:#450a0a;color:#fca5a5}[data-theme=dark] .pi-profile__flags{background:#450a0a}.brief-view{max-width:900px}.brief-text{white-space:pre-wrap;line-height:1.7;font-size:.95rem}.brief-table{width:100%;border-collapse:collapse;font-size:.85rem;margin-top:12px}.brief-table th,.brief-table td{padding:8px 12px;text-align:left;border-bottom:1px solid var(--border, #e0e0e0)}.brief-table th{font-weight:600;opacity:.8;font-size:.8rem;text-transform:uppercase}.brief-narrative{margin-bottom:16px;padding-bottom:16px;border-bottom:1px solid var(--border, #e0e0e0)}.brief-narrative:last-child{border-bottom:none}.brief-narrative h3{font-size:.95rem;margin-bottom:4px}.brief-narrative p{font-size:.9rem;line-height:1.6;opacity:.9}.brief-stats{display:flex;gap:48px}.brief-recommendations{padding-left:20px;line-height:1.8;font-size:.9rem}.brief-recommendations li{margin-bottom:8px}